Expression of ENPP1 in Testicular Germ Cell Tumors: Exploring Its Role in the Pathobiology of Distinct Histotypes and in Prognosis
We demonstrate that ENPP1 is expressed in TGCTs, mostly EC (a frequently aggressive tumor subtype), followed by seminoma (the most common TGCT subtype), suggesting potential responsiveness to novel ENPP1 inhibitors. Absent expression in germ cells of healthy testicular parenchyma suggest cancer cells specificity and low probability of fertility-related toxicity.
Authors
- Isaac Braga (ORCID: https://orcid.org/0000-0001-9265-4324)
- Paula Lopes (ORCID: https://orcid.org/0000-0002-2150-051X)
- Cármen Jerónimo (ORCID: https://orcid.org/0000-0003-4186-5345)
- Joaquina Maurício
- Rui Henrique (ORCID: https://orcid.org/0000-0003-3171-4666)
- Nuno Tiago Tavares (ORCID: https://orcid.org/0000-0001-8426-1838)
- Rita de Cássia Avellaneda Guimarães (ORCID: https://orcid.org/0000-0001-9324-7018)
- João Lobo (ORCID: https://orcid.org/0000-0001-6829-1391)
- M. Alves (ORCID: https://orcid.org/0000-0002-7506-5525)
- A.T. Lapa
- Fernanda Fernandes‐Pontes (ORCID: https://orcid.org/0009-0007-3931-0443)
Institutions
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
Publication Details
- Journal
- Pathobiology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1159/000547655
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00