Successful Ventriculoamniotic Shunting for Fetal Hydrocephalus in the Ovine Model
Hydrocephalus was induced in 87% of fetal sheep using this model. In an ovine model, ventriculoamniotic shunting both decreased the degree of hydrocephalus sonographically and improved brain histology compared to hydrocephalic controls. These findings demonstrate proof of concept in the animal model and support ongoing research in cerebrospinal fluid diversion for fetal obstructive hydrocephalus.
Authors
- Youngjae Chun (ORCID: https://orcid.org/0000-0002-4522-7116)
- Nika M. Hazen
- Stephen P. Emery (ORCID: https://orcid.org/0000-0002-8539-7566)
- Lora H. Rigatti (ORCID: https://orcid.org/0000-0003-3921-0593)
- Stephanie Greene (ORCID: https://orcid.org/0000-0002-5858-4032)
Institutions
- University of Pittsburgh (US)
- Magee-Womens Hospital (US)
- UPMC Hillman Cancer Center (US)
- Duke Children's Hospital & Health Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Fetal Diagnosis and Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1159/000547610
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00