Avelumab plus cetuximab in patients with unresectable stage III or IV cutaneous squamous cell carcinoma: clinical activity and safety results from AliCe, a single-arm multicentre phase II DeCOG trial
Avelumab in combination with cetuximab demonstrates encouraging clinical activity in advanced cSCC, including patients with challenging subgroups such as perianogenital primaries or those with disease that has progressed on anti-PD-1 monotherapy. This is especially true when patients are carefully selected for their ability to undergo treatment for at least 12 weeks.
Authors
- Christine Windemuth-Kieselbach
- Bastian Schilling (ORCID: https://orcid.org/0000-0001-8859-4103)
- Alexandra N Spillner
- Ralf Gutzmer (ORCID: https://orcid.org/0000-0001-7921-2820)
- Anja Gesierich
- Yenny Angela (ORCID: https://orcid.org/0000-0002-6643-7286)
- Elisabeth Livingstone (ORCID: https://orcid.org/0000-0001-8279-9239)
- Thomas Eigentler (ORCID: https://orcid.org/0000-0003-0019-2770)
- Selma Ugurel (ORCID: https://orcid.org/0000-0002-9384-6704)
- Lisa Zimmer (ORCID: https://orcid.org/0000-0002-3680-3521)
- Jürgen Christian Becker (ORCID: https://orcid.org/0000-0001-9183-653X)
- Jessica Cecile Hassel (ORCID: https://orcid.org/0000-0001-7575-6230)
- Michael Fluck
- Mirjana Ziemer (ORCID: https://orcid.org/0000-0001-6488-1917)
- Ulrike Leiter (ORCID: https://orcid.org/0000-0002-8019-1577)
- Friedegund Meier
- Imke von Wasielewski
Institutions
- Goethe University Frankfurt (DE)
- Heidelberg University (DE)
- Skin Cancer Foundation (US)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- West Cancer Center (US)
- National Center for Tumor Diseases (DE)
- Essen University Hospital (DE)
- University Children's Hospital Tübingen (DE)
- University Hospital Leipzig (DE)
- Universitätsklinikum Würzburg (DE)
- Klinikum Bielefeld (DE)
- University Hospital Frankfurt (DE)
- Giessen School of Theology (DE)
- DKFZ-ZMBH Alliance (DE)
- Fachklinik Hornheide (DE)
- Johannes Wesling Klinikum Minden (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1093/bjd/ljaf303
- Citations
- 3
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06