CALS and ACB Scales are Associated with Physical and Cognitive Impairment and Predict Mortality in Nursing Home Residents
In this cohort of nursing home residents, anticholinergic burden as measured by both CALS and ACB was associated with baseline physical impairment and 3-year mortality, but CALS showed a better goodness of fit. Between the two scales, CALS only was independently associated with baseline cognitive impairment. These findings support the clinical utility of CALS in assessing anticholinergic-related risk among frail older adults in institutional settings.
Authors
- Luca Soraci (ORCID: https://orcid.org/0000-0002-0171-3358)
- Francesco Bruno (ORCID: https://orcid.org/0000-0003-1377-4489)
- Giuseppe Passarino (ORCID: https://orcid.org/0000-0003-4701-9748)
- Salvatore Claudio Cosimo
- Francesco Morelli (ORCID: https://orcid.org/0000-0002-5149-6291)
- Alberto Montesanto (ORCID: https://orcid.org/0000-0002-9563-2216)
- Andrea Corsonello (ORCID: https://orcid.org/0000-0002-7276-3256)
- Ersilia Paparazzo (ORCID: https://orcid.org/0000-0002-9593-9314)
- Mirella Aurora Aceto (ORCID: https://orcid.org/0009-0000-9836-6876)
- Teresa Serra Cassano
- Maria Princiotto
- Davide Lagrotteria (ORCID: https://orcid.org/0000-0002-7241-9180)
- Pierluigi Mercatante
Institutions
- Mercatorum University (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- University of Florence (IT)
- University of Calabria (IT)
- Biotronik (Switzerland) (CH)
Publication Details
- Journal
- Drugs - Real World Outcomes
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1007/s40801-025-00509-7
- Citations
- 1
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- Ministero della Salute