Inflammatory memory in allergic diseases

In allergic diseases, patients experience the recurrent suffering driven not only by adaptive immunity but also by non-adaptive immune memory, primarily mediated through epigenetic reprogramming. This review explores the role of inflammatory memory in common allergic conditions—such as asthma, rhinitis, food allergies, and atopic dermatitis—and synthesizes current research on its contribution to disease recurrence. Furthermore, we examine how different therapeutic strategies may alter disease progression by targeting inflammatory memory. Moving forward, advanced technologies like single-cell and spatial omics will be essential to unravel the complex landscape of inflammatory memory and develop precise, long-term treatments, ultimately enabling better management of allergic diseases.