Effectiveness of repeated Esketamine nasal spray administration on anhedonic symptoms in treatment-resistant bipolar and unipolar depression: A secondary analysis from the REAL-ESK study group
Repeated administration of ESK-NS effectively reduces anhedonia in both unipolar and bipolar depression patients in real-world settings, suggesting a targeted, transdiagnostic anti-anhedonic effect beyond general antidepressant action.
Authors
- Ileana Andriola (ORCID: https://orcid.org/0000-0001-5023-5287)
- Marco Di Nicola (ORCID: https://orcid.org/0000-0001-7457-0426)
- F. Cuccia
- Giovanni Martinotti
- Sergio Barlati (ORCID: https://orcid.org/0000-0002-1784-3915)
- Matteo Vismara (ORCID: https://orcid.org/0000-0002-9533-8615)
- Matteo Marcatili (ORCID: https://orcid.org/0000-0002-1436-1961)
- Raffaella Zanardi (ORCID: https://orcid.org/0000-0001-5941-5663)
- Stefano Luca Sensi (ORCID: https://orcid.org/0000-0002-0710-2574)
- Mauro Pettorruso (ORCID: https://orcid.org/0000-0002-4164-3040)
- Massimo Clerici (ORCID: https://orcid.org/0000-0001-8769-6474)
- Sergio De Filippis (ORCID: https://orcid.org/0000-0002-6521-3379)
- Antonio Vita (ORCID: https://orcid.org/0000-0002-3621-6394)
- Maria Salvina Signorelli (ORCID: https://orcid.org/0000-0002-6941-9454)
- Gianluca Rosso (ORCID: https://orcid.org/0000-0002-2308-9146)
- Clara Cavallotto
- Fabiola Raffone (ORCID: https://orcid.org/0000-0002-1818-4237)
- Gabriele Tamagnini
- Tommaso Vannucchi
- Domenico De Berardis (ORCID: https://orcid.org/0000-0003-4415-5058)
- Maria Pepe (ORCID: https://orcid.org/0009-0002-7597-6916)
- L Santé (ORCID: https://orcid.org/0000-0002-2200-0445)
- Andrea Barra
- Roger S. McIntyre (ORCID: https://orcid.org/0000-0003-4733-2523)
- Rosalba Carullo
- Luca Persico (ORCID: https://orcid.org/0000-0002-5436-2627)
- Gabriele Di Salvo (ORCID: https://orcid.org/0000-0002-0085-8731)
- Gianluca Serafini (ORCID: https://orcid.org/0000-0002-6631-856X)
- Giorgio Pigato
- Giorgio Di Lorenzo (ORCID: https://orcid.org/0000-0002-0576-4064)
- Giulia Castellani (ORCID: https://orcid.org/0000-0001-6151-015X)
- Matteo Carminati
- Giacomo d’Andrea (ORCID: https://orcid.org/0000-0002-6808-3960)
- Andrew D. Santeusanio (ORCID: https://orcid.org/0000-0002-4575-5330)
- A. Petralia (ORCID: https://orcid.org/0000-0002-2163-1608)
- Angelo De Giorgi
- Antonio d'Attilio
- Giovanna Mammarella
- Chiara Di Natale
- Monica Bosi
- Vassillis Martiadis
- Bernardo Maria Dell’Osso
- Serena Panichella
- Andreea C. MOSULET
Institutions
- University of Foggia (IT)
- University of Rome Tor Vergata (IT)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Catania (IT)
- University of Chieti-Pescara (IT)
- Brain and Cognition Discovery Foundation (CA)
- Villa Melitta (IT)
- Ospedale Policlinico San Martino (IT)
- Hospital of Prato (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- University of Milano-Bicocca (IT)
- University of Brescia (IT)
- PRA Health Sciences (US)
Publication Details
- Journal
- Psychiatry Research
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.psychres.2025.116655
- Citations
- 9
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 12.55