Subchronic amphetamine decreases hyperactivity, anti-social behaviour and anhedonia in dopamine transporter knockout rats: role of prefrontal glutamate
Subchronic amphetamine treatment decreased the hyperactivity, anxiety-like, anti-social and anhedonic phenotypes of female DAT KO rats, potentially by modulating glutamate transmission in the prefrontal cortex. These findings foster further research into the treatment of hyperdopaminergia-related disorders.
Authors
- Lucia Caffino (ORCID: https://orcid.org/0000-0001-8045-3146)
- Erwin H. van den Burg (ORCID: https://orcid.org/0000-0002-0980-7543)
- Fabio Fumagalli (ORCID: https://orcid.org/0000-0002-8814-7706)
- Francesca Mottarlini (ORCID: https://orcid.org/0000-0001-8172-1384)
- Damiana Leo (ORCID: https://orcid.org/0000-0001-9219-5498)
- Fabrizio Sanna (ORCID: https://orcid.org/0000-0002-9923-4231)
- Judith Regina Homberg (ORCID: https://orcid.org/0000-0002-7621-1010)
- Kyriaki Foka (ORCID: https://orcid.org/0000-0003-0466-5424)
- Sofia Taddini
- Mina Sadighi
Institutions
- University of Mons (BE)
- Radboud University Nijmegen (NL)
- University of Cagliari (IT)
- University of Milan (IT)
- MRC Cognition and Brain Sciences Unit (GB)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- University of Lausanne (CH)
Publication Details
- Journal
- Neuropharmacology
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1016/j.neuropharm.2025.110597
- Citations
- 1
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek