Vasoactive intestinal peptide reduces ocular hypertension by regulating tight junction of trabecular meshwork through Rab13/PKA signalling complex
VIP inhibited TJ of TM cells by regulating the Rab13-PKA signalling complex, leading to the reduction of ocular hypertension in rats. This study provides new sights for the treatment of ocular hypertension.
Authors
- Xiaoqin Yan (ORCID: https://orcid.org/0000-0001-8055-2013)
- Mu Li (ORCID: https://orcid.org/0000-0002-2371-8950)
- Liwen Chen (ORCID: https://orcid.org/0000-0003-4705-4754)
- Yang Cheng (ORCID: https://orcid.org/0000-0003-3398-9428)
- Zhaoxia Luo
Institutions
- Union Hospital (HK)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1080/07853890.2025.2534527
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00