Metabolism-related gene PDK1 regulates myocardial cell remodeling and its mechanism
Our study established a PDK1 knockout model under hypoxia that exhibits mitochondrial metabolism dysregulation, elevated oxidative stress, and decreased cell viability. This model is an important tool for understanding the mechanism of hypoxia-induced myocardial apoptosis, elucidating the gene-phenotype relationship of PDK1 deficiency, and providing evidence to mitigate the damage against hypoxia.
Authors
- Hongfeng Jiang (ORCID: https://orcid.org/0000-0002-9261-0433)
- Feng Lan (ORCID: https://orcid.org/0000-0002-9038-4014)
- Muhammad Khawar Abbas (ORCID: https://orcid.org/0000-0001-7804-0748)
- Amina Saleem (ORCID: https://orcid.org/0000-0002-3064-4750)
- Shuhong Ma (ORCID: https://orcid.org/0000-0002-9271-8030)
- Fan Jiaqi
- Mingyu Wei
- Siyao Zhang (ORCID: https://orcid.org/0009-0006-0027-8776)
Institutions
- Islamia University of Bahawalpur (PK)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Institute of Water (CN)
- Peking University Third Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13287-025-04518-9
- Citations
- 2
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China