NEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes
We demonstrated that NEXN was one of the important components in maintaining the structure and function of cardiomyocyte junctional membrane complexes (JMCs), excitation-contraction coupling and energy metabolism of cardiomyocytes, while the loss of its function would lead to DCM. This model represents an important tool to gain insight into the mechanism of DCM, elucidate the gene-phenotype relationship of NEXN deficiency and facilitate drug screening.
Authors
- Feng Lan (ORCID: https://orcid.org/0000-0002-9038-4014)
- Ming Cui (ORCID: https://orcid.org/0000-0002-1173-0645)
- Yun Bai (ORCID: https://orcid.org/0000-0002-2688-9229)
- Mingyu Wei
- Yuanxiu Song (ORCID: https://orcid.org/0000-0002-2031-431X)
- Xi Chen (ORCID: https://orcid.org/0000-0002-0178-720X)
- Jixiang Cao
- Mengqi Jiang (ORCID: https://orcid.org/0000-0001-7328-7442)
- Wenjing Lü (ORCID: https://orcid.org/0000-0001-5463-0946)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13287-025-04484-2
- Citations
- 1
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University Third Hospital