Ammoxidation of Methylarenes Mediated by a Photo-/Iron Relay
A photothermal coupling system comprising NH<sub>2</sub>OH·HCl, NH<sub>4</sub>Cl, and Fe<sub>2</sub>(SO<sub>4</sub>)<sub>3</sub> has been developed for the direct ammoxidation of methylarenes under O<sub>2</sub> and long-wavelength ultraviolet (UV) light (UVA) irradiation. This light-driven system is applicable to a broad spectrum of methylarenes, facilitating access to diverse aryl nitriles, which are ubiquitous in the field of fine chemicals. Mechanistic investigations suggest that the reaction is an integration of two steps: chlorine-radical-mediated photooxidation and subsequent Fe<sup>3+</sup>-promoted thermal cyanation via a five-membered cyclic Fe<sup>3+</sup>-dioxime complex.
Authors
- Chao Feng (ORCID: https://orcid.org/0000-0003-4494-6845)
- Jieqing Wu
- Zhangyi Wang (ORCID: https://orcid.org/0000-0001-6370-8848)
- Yu‐Feng Li (ORCID: https://orcid.org/0000-0002-1071-3915)
- Tingting Zhu (ORCID: https://orcid.org/0000-0002-1552-5630)
- Yujie Fan (ORCID: https://orcid.org/0000-0002-5221-6300)
- Yi Wang (ORCID: https://orcid.org/0000-0002-8700-7621)
- Yutao Wang (ORCID: https://orcid.org/0000-0002-4087-9334)
- Hongjun Zhu
- Hao-Yue Zhang
- Xiaoyu Wang
Institutions
- Nanjing Tech University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1021/acs.joc.5c01208
- Primary Topic
- Advanced Photocatalysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China