Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis
PEMF accelerates early-stage differentiation of human cortical neurons and enhances synaptic maturation following sustained stimulation. These effects are mechanistically linked to the activation of FDFT1-mediated cholesterol biosynthesis. This non-invasive PEMF stimulation approach represents a promising strategy to optimize stem cell-based therapies for neurological disorders.
Authors
- Weihua Meng (ORCID: https://orcid.org/0000-0001-5388-8494)
- Weiming Tian (ORCID: https://orcid.org/0000-0003-4958-4118)
- Simin Song
- Bing Song (ORCID: https://orcid.org/0000-0001-9356-2333)
- Xianyang Luo
- Ping Chen (ORCID: https://orcid.org/0000-0001-7995-6168)
- Ruixin Dong (ORCID: https://orcid.org/0000-0001-9343-0082)
- Liping Guo (ORCID: https://orcid.org/0000-0002-9989-6278)
- Min Tao (ORCID: https://orcid.org/0000-0001-9439-2153)
- Vsevolod Telezhkin (ORCID: https://orcid.org/0000-0002-5054-8774)
- Yu Gu (ORCID: https://orcid.org/0000-0003-2156-8407)
- Qian Liu (ORCID: https://orcid.org/0000-0002-1937-0568)
- Yan Wang (ORCID: https://orcid.org/0000-0003-0671-7312)
- Jingyi Li (ORCID: https://orcid.org/0000-0003-3304-5005)
- Wei Hong
Institutions
- University of Nottingham Ningbo China (CN)
- Harbin Institute of Technology (CN)
- University Town of Shenzhen (CN)
- Newcastle Dental Hospital (GB)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Technology University (CN)
- Newcastle University (GB)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13287-025-04469-1
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Key Technologies Research and Development Program
- Science and Technology Planning Project of Guangdong Province
- International Cooperation Project of Ningbo City