Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis
This study highlights the pivotal role of the gut microbiome, specifically propionic acid and B. fragilis, in modulating the efficacy of combined radiotherapy and immunotherapy in MSS-CRC.
Authors
- Yanqing Ding (ORCID: https://orcid.org/0000-0003-1775-6923)
- Zhenhui Chen (ORCID: https://orcid.org/0000-0001-7680-533X)
- Qiqing Guo (ORCID: https://orcid.org/0000-0003-4387-2549)
- Yi� Ding (ORCID: https://orcid.org/0000-0001-5035-9255)
- Yaowei Zhang (ORCID: https://orcid.org/0000-0001-7756-6756)
- Zihuan Wang (ORCID: https://orcid.org/0009-0001-0769-3618)
- Lu Yu (ORCID: https://orcid.org/0000-0003-4073-3842)
- Jiaying Li (ORCID: https://orcid.org/0000-0001-7508-1579)
- Yafang Wang
- Yuqin Zhang (ORCID: https://orcid.org/0000-0001-5629-0770)
- Xusheng Wang (ORCID: https://orcid.org/0000-0002-1759-9588)
- Xinyi Gu (ORCID: https://orcid.org/0000-0002-4059-2026)
- Zi Xu
- Ke-Li Chen
Institutions
- Army Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Shanghai Ninth People's Hospital (CN)
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- Xinqiao Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1038/s41416-025-03105-2
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China