A spurious fln-2 mutation in a wide variety of commonly used C. elegans strains
We describe a <i>fln-2</i> mutant allele present in many commonly used <i>Caenorhabditis elegans</i> strains. It is present in the <i>dpy-5 ( e907 )</i> strain, ancestral to thousands of transgenic strains generated by the <i>C. elegans</i> Expression Project. This finding broadens the number of strains affected by the <i>fln-2</i> mutation, now impacting thousands of transgenic lines used in diverse studies. This expands on the previous identification of <i>the fln-2</i> mutation in a wild-type male stock strain used for outcrossing in genetic studies.
Authors
- Gary Ruvkun (ORCID: https://orcid.org/0000-0002-7473-8484)
- Marina Kniazeva
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-07
- DOI
- https://doi.org/10.17912/micropub.biology.001684
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00