A spurious fln-2 mutation in a wide variety of commonly used C. elegans strains

We describe a <i>fln-2</i> mutant allele present in many commonly used <i>Caenorhabditis elegans</i> strains. It is present in the <i>dpy-5 ( e907 )</i> strain, ancestral to thousands of transgenic strains generated by the <i>C. elegans</i> Expression Project. This finding broadens the number of strains affected by the <i>fln-2</i> mutation, now impacting thousands of transgenic lines used in diverse studies. This expands on the previous identification of <i>the fln-2</i> mutation in a wild-type male stock strain used for outcrossing in genetic studies.

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Journal
PubMed
Published
2025-06-07
DOI
https://doi.org/10.17912/micropub.biology.001684
Primary Topic
Genetics, Aging, and Longevity in Model Organisms
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article
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article

A spurious fln-2 mutation in a wide variety of commonly used C. elegans strains

Gary Ruvkun, Marina Kniazeva
PubMed
Genetics, Aging, and Longevity in Model Organisms
article

A spurious fln-2 mutation in a wide variety of commonly used C. elegans strains

Gary Ruvkun, Marina Kniazeva
article en

Abstract

We describe a <i>fln-2</i> mutant allele present in many commonly used <i>Caenorhabditis elegans</i> strains. It is present in the <i>dpy-5 ( e907 )</i> strain, ancestral to thousands of transgenic strains generated by the <i>C. elegans</i> Expression Project. This finding broadens the number of strains affected by the <i>fln-2</i> mutation, now impacting thousands of transgenic lines used in diverse studies. This expands on the previous identification of <i>the fln-2</i> mutation in a wild-type male stock strain used for outcrossing in genetic studies.

PubMedVol. 2025
Harvard University (US), Massachusetts General Hospital (US)
Openalex Percentile: Top 85%
Genetics, Aging, and Longevity in Model Organisms
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