Multiclonal Profiling of FLT3-ITD in AML Using MinION Sequencing: A Tailored Clustering Approach to Enhance Subclonal Detection.
Third-generation sequencing combined with a tailored clustering strategy enhances the detection of FLT3-ITDs and clonal diversity in AML compared to generic variant callers. This method provides critical insights into subclonal populations driving relapse and therapeutic resistance-particularly in relapsed/refractory AML-underscoring the importance of specialized pipelines for precision medicine in leukemia.
Authors
- Antonio M. Gutierrez (ORCID: https://orcid.org/0000-0001-9062-077X)
- Oliver Vögler (ORCID: https://orcid.org/0000-0002-9234-1456)
- Antònia Sampol (ORCID: https://orcid.org/0000-0001-7465-6203)
- Jordi Martínez-Serra
- Paula Gómez
- Aser Alonso-Carballo
- Ángel Horrillo
Institutions
- Health Research Institute of the Balearic Islands (ES)
- Hospital Universitario Son Espases (ES)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/ott.s526628
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00