Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation
Metabolic stress represents a critical barrier to PRPC survival following transplantation. Strategies aimed at enhancing metabolic resilience may improve transplantation outcomes. Furthermore, host retinal responses shape the transplant microenvironment, influencing donor cell survival and integration. These findings highlight the need for targeted interventions to mitigate early metabolic stress and optimize PRPC transplantation strategies for retinal degenerative diseases.
Authors
- William A. Beltran (ORCID: https://orcid.org/0000-0002-1127-4774)
- Alexa Gray (ORCID: https://orcid.org/0000-0003-1858-1491)
- Praveen Joseph Susaimanickam (ORCID: https://orcid.org/0000-0002-1567-1312)
- John H. Wolfe (ORCID: https://orcid.org/0000-0002-7497-3943)
- Geoffrey K. Aguirre (ORCID: https://orcid.org/0000-0002-4028-3100)
- Jennifer Kwok (ORCID: https://orcid.org/0000-0002-1995-0095)
- Emil Kryukov (ORCID: https://orcid.org/0000-0001-8506-0448)
- Yu Sato (ORCID: https://orcid.org/0000-0002-5940-1349)
- Raghavi Sudharsan (ORCID: https://orcid.org/0000-0001-7839-5178)
- David M. Gamm (ORCID: https://orcid.org/0000-0002-8152-613X)
- Petr Baranov (ORCID: https://orcid.org/0000-0002-5526-7058)
- Natalia V. Dolgova (ORCID: https://orcid.org/0000-0002-9951-6634)
- Agustin Luz Madrigal
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Children's Hospital of Philadelphia (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Massachusetts Eye Research and Surgery Institute (US)
- Smith-Kettlewell Eye Research Institute (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s13287-025-04509-w
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Foundation Fighting Blindness
- Research to Prevent Blindness
- University of Pennsylvania
- Retina Research Foundation
- Foundation Fighting Blindness
- National Institutes of Health
- National Eye Institute