Dissecting the biology of gliomagenesis: Evaluating the interaction between <i>IDH</i> tumor mutation and germline variants
To understand the development of adult glioma, we demonstrate that <i>D2HGDH</i> and <i>PHLDB1</i> should be prioritized for functional studies in <i>IDH</i>mut tumors. The <i>ROBO1</i> region warrants further investigation in <i>IDH</i>wt tumors.
Authors
- Gian Marco Conte (ORCID: https://orcid.org/0000-0001-5926-7517)
- Terry C. Burns (ORCID: https://orcid.org/0000-0001-7633-3045)
- Bradley J. Erickson (ORCID: https://orcid.org/0000-0001-7926-6095)
- Thomas M. Kollmeyer (ORCID: https://orcid.org/0000-0002-0694-3224)
- John K. Wiencke (ORCID: https://orcid.org/0000-0001-7101-6489)
- Mana Moassefi (ORCID: https://orcid.org/0000-0002-0111-7791)
- Stephen Francis (ORCID: https://orcid.org/0000-0002-6488-6272)
- Rachael A. Vaubel (ORCID: https://orcid.org/0000-0001-8842-5975)
- Annette M. Molinaro (ORCID: https://orcid.org/0000-0002-9854-7404)
- Kristen Drucker (ORCID: https://orcid.org/0000-0001-6244-5863)
- Matthew Kosel (ORCID: https://orcid.org/0009-0008-5787-0134)
- Jeanette E. Eckel‐Passow (ORCID: https://orcid.org/0000-0002-6113-1114)
- Daniel H. Lachance (ORCID: https://orcid.org/0000-0002-5475-9931)
- Robert B. Jenkins (ORCID: https://orcid.org/0000-0002-4049-694X)
- Paul A. Decker (ORCID: https://orcid.org/0000-0002-3756-4227)
- Margaret Wrensch (ORCID: https://orcid.org/0000-0002-3070-7600)
- William Oliver Tobin (ORCID: https://orcid.org/0000-0002-8141-2394)
- Anne K. Shurtz
Institutions
- Mayo Clinic (US)
- University of California, San Francisco (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf147
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- University of California, San Francisco