Alteration of Cytokine/Chemokine Transcript Levels in the Placenta of Humanized Mouse Models Treated Prenatally With Dexamethasone
Cxcl10 is overexpressed during DEX-induced placental damage in the mouse models, suggesting it as a potential biomarker of placental damage. Further studies are needed to confirm Cxcl10 changes during placental damage induced by other placental toxicants.
Authors
- Kyung E. Sung (ORCID: https://orcid.org/0000-0001-9664-6399)
- Noriko Nakamura (ORCID: https://orcid.org/0000-0002-1787-3049)
- JG Moore
- Brian J. Kwee (ORCID: https://orcid.org/0000-0002-4426-1363)
- Kelly Cue Davis (ORCID: https://orcid.org/0000-0002-2055-4858)
- Xiaoqing Li (ORCID: https://orcid.org/0000-0002-9815-6040)
Institutions
- National Center for Toxicological Research (US)
- Center for Biologics Evaluation and Research (US)
- United States Food and Drug Administration (US)
Publication Details
- Journal
- Birth Defects Research
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1002/bdr2.2514
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Food and Drug Administration