A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy
We develop a unique trident-like multi-cationic photosensitizer (PS) with an acceptor-donor-acceptor (A-D-A) structure to enhance photodynamic therapy (PDT). The design minimizes PS leakage from membrane camouflaged nanoparticles (<1% in 24 h) <i>via</i> hydrophilic anchoring, while boosting ROS generation (13.8-fold higher <sup>1</sup>O<sub>2</sub> than Rose Bengal) through excited state optimization, thus significantly improving tumor-targeted PDT efficiency.
Authors
- Chengyun Wang (ORCID: https://orcid.org/0000-0002-2470-3291)
- Weijun Zhao (ORCID: https://orcid.org/0000-0002-7696-7133)
- Guang Hua Yi
- Jiayi Li (ORCID: https://orcid.org/0000-0002-8041-8049)
- Chen Peng (ORCID: https://orcid.org/0000-0002-7568-5409)
- Qiqi Xu (ORCID: https://orcid.org/0009-0000-7685-5572)
- Ying Wang (ORCID: https://orcid.org/0000-0001-6638-8026)
Institutions
- East China University of Science and Technology (CN)
- Shanghai Public Health Clinical Center (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02248g
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China