A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47
Overall, the single gain-of-function SM mimics the UPR-mediated p53 stress response, by generating RNA secondary structures akin to the PERK-mediated p53 mRNA structural switch. This illustrates the link between RNA structures and cellular biology and underscores the importance of SMs in cancer biology and their potential to further refine genetic diagnostics.
Authors
- Konstantinos Karakostis (ORCID: https://orcid.org/0000-0003-1122-7860)
- Sivakumar Vadivel Gnanasundram (ORCID: https://orcid.org/0000-0001-9153-0784)
- Sa Chen
- Robin Fåhræus (ORCID: https://orcid.org/0000-0003-0402-8492)
- Olivera Casar‐Borota (ORCID: https://orcid.org/0000-0001-7376-7331)
- Lixiao Wang
- GU Xiao-lian
- Rhythm Sajwan
Institutions
- Uppsala University (SE)
- Inserm (FR)
- Universitat de València (ES)
- Indian Institute of Technology Palakkad (IN)
- Masaryk Memorial Cancer Institute (CZ)
- Hospital Del Mar (ES)
- Umeå University (SE)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1038/s41416-025-03127-w
- Citations
- 2
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Cancerfonden
- Umeå Universitet
- Servier
- Medicinska fakulteten, Umeå Universitet