Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration
GAD65 antibodies directly affect neuronal viability and network activity. Co-existing autoantibodies against CN1A, present in anti-GAD65-positive patients, enhance autophagy and subsequent neuronal death in vitro. Clinically, anti-GAD65-positive patients should be screened for anti-CN1A-associated diseases, and evaluation of anti-CN1A in anti-GAD65-related autoimmune conditions may clarify links between systemic autoimmunity and epilepsy.
Authors
- Albert J. Becker (ORCID: https://orcid.org/0000-0003-2661-3705)
- Annika Breuer
- Franziska Thaler
- Julika Pitsch (ORCID: https://orcid.org/0000-0002-6688-4916)
- Delara Kamalizade
- Lars Komorowski (ORCID: https://orcid.org/0000-0003-4698-3316)
- Christoph Helmstaedter (ORCID: https://orcid.org/0000-0002-6608-6244)
- Susanne Schoch (ORCID: https://orcid.org/0000-0002-2046-2670)
- Rainer Surges (ORCID: https://orcid.org/0000-0002-3177-8582)
- Tobias Baumgartner (ORCID: https://orcid.org/0000-0001-5935-9841)
- Thoralf Opitz (ORCID: https://orcid.org/0009-0001-2419-5004)
- Juliane L Berns
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- LMU Klinikum (DE)
- Euroimmun Medizinische Labordiagnostika (Germany) (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s12974-025-03521-4
- Citations
- 3
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Deutsche Forschungsgemeinschaft
- Rheinische Friedrich-Wilhelms-Universität Bonn