Adrenal Dysfunction in Outpatients with Decompensated Cirrhosis: Impairment in the Hypothalamic–Pituitary–Adrenal Axis
Inappropriately low ACTH secretion and alterations in adrenal steroidogenesis are associated with an abnormal response to ACTH stimulation testing in outpatients with decompensated cirrhosis. These findings suggest multilevel HPA axis dysfunction and support the theory that AD represents cirrhosis-induced extrahepatic organ failure. The presence of AD may not be associated with worse liver-related outcomes.
Authors
- Wendy M. Novicoff (ORCID: https://orcid.org/0000-0002-5146-7706)
- Calvin Geng (ORCID: https://orcid.org/0000-0001-7583-9191)
- Helmy M. Siragy (ORCID: https://orcid.org/0000-0001-8121-9052)
- Brian J. Wentworth (ORCID: https://orcid.org/0000-0003-3642-887X)
- Zachary Henry
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1007/s10620-025-09237-y
- Citations
- 1
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- American Association for the Study of Liver Diseases
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences