New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines
4T1luc2 cells stably expressing HPV16 E6/E7 present an attractive alternative to TC-1 model allowing stringent assessment of both protective and therapeutic potential of E6/E7-based vaccines in BALB/c mice.
Authors
- Lība Sokolovska (ORCID: https://orcid.org/0000-0002-5820-1783)
- Dmitry Perminov
- Jurijs Nazarovs
- Alesja Dudorova (ORCID: https://orcid.org/0000-0001-9444-4689)
- Hermann Nicolai (ORCID: https://orcid.org/0000-0003-1786-1432)
- Dace Skrastiņa (ORCID: https://orcid.org/0000-0001-5836-6441)
- Juris Jansons (ORCID: https://orcid.org/0000-0003-0845-4392)
- Darya Avdoshina (ORCID: https://orcid.org/0000-0001-8168-5969)
- Joel M. Palefsky (ORCID: https://orcid.org/0000-0002-5097-3818)
- Ilze Lindenberga
- Sona Chowdhury
- Maria Isaguliants
- E. Rubio
- Svetlana Gebrila
Institutions
- Latvian Biomedical Research and Study Centre (LV)
- University of California, San Francisco (US)
- Riga Stradiņš University (LV)
Publication Details
- Journal
- Infectious Agents and Cancer
- Published
- 2025-07-26
- DOI
- https://doi.org/10.1186/s13027-025-00682-y
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Narodowa Agencja Wymiany Akademickiej
- National Institutes of Health