Spermine: A prospective treatment for high glucose-induced myocardial fibrosis in db/db mice.
Our findings demonstrate that SP reduces collagen synthesis and secretion by inhibiting the TGF-β1/Smads signaling pathway. These results provide new insights into potential therapeutic approaches for DCM.
Authors
- Hui Yuan (ORCID: https://orcid.org/0000-0001-5646-9447)
- Yong Liu (ORCID: https://orcid.org/0000-0002-4048-5837)
- Shuang Li (ORCID: https://orcid.org/0000-0002-0550-8722)
- Xinyu Liu (ORCID: https://orcid.org/0000-0003-1981-148X)
- Tao Wang (ORCID: https://orcid.org/0000-0001-7887-1074)
- Tong Xu (ORCID: https://orcid.org/0009-0002-7343-2157)
- Yang Lü (ORCID: https://orcid.org/0000-0003-1212-5508)
Institutions
- Mudanjiang Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.83464.18060
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00