Daidzein improves neuronal health and alleviates inflammation and apoptosis through BDNF and estrogen receptors in the hippocampus of ovariectomized rats.
DDZ effectively reversed the stereological changes in the CA1 region by stimulating BDNF gene expression, increasing the phosphorylation ratio of the GSK-3β protein, and modulating inflammatory and apoptotic pathways. Although its effects on the DG region, BDNF, and ERα molecules were less significant than E2, DDZ could still be a promising candidate for ameliorating ED.
Authors
- Fatemeh Keshavarzi (ORCID: https://orcid.org/0000-0002-1131-107X)
- Zahra Khoshdel (ORCID: https://orcid.org/0000-0003-2539-9997)
- Fatemeh Zal (ORCID: https://orcid.org/0000-0002-7078-4854)
- Farhad Koohpeyma (ORCID: https://orcid.org/0000-0001-6729-7732)
- Sanaz Alaee (ORCID: https://orcid.org/0000-0003-4490-8830)
- Asma Neisy (ORCID: https://orcid.org/0000-0003-4372-5522)
- Zohreh Mostafavi‐Pour (ORCID: https://orcid.org/0000-0002-3779-177X)
- Atefeh Seghatoleslam (ORCID: https://orcid.org/0000-0002-8277-6608)
- Saeed Shokri (ORCID: https://orcid.org/0000-0001-9245-3653)
Institutions
- The University of Sydney (AU)
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.82074.17758
- Citations
- 1
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Shiraz University of Medical Sciences
- Shiraz University