Thymoquinone prevents valproic acid-induced hepatotoxicity via modulation of cytochrome P450, PPARs, and apoptotic pathways.
TQ substantially protects liver tissue by modifying gene expression, lowering oxidative stress, and increasing liver function. It significantly counteracts VPA's toxic effects, demonstrating its promise as a hepatoprotective agent in avoiding liver damage.
Authors
- Sebile Azırak (ORCID: https://orcid.org/0000-0001-9040-6773)
- Mehmet Nur Kaya (ORCID: https://orcid.org/0000-0003-4368-3078)
- Sedat Bilğiç (ORCID: https://orcid.org/0000-0001-8410-2685)
- Deniz Taştemir Korkmaz (ORCID: https://orcid.org/0000-0001-5844-8914)
- İlkay Armağan (ORCID: https://orcid.org/0000-0002-8080-9429)
Institutions
- Adıyaman University (TR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.85190.18407
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Adiyaman Üniversitesi