Multi-Target Synergy Against Acute Lung Injury: Systems Pharmacology Decoding Dahuang-Huangqin Herb Pair's Therapeutic Mechanism.
This study elucidates DH-HQ's multi-target mechanism in mitigating ALI via synergistic bioactive components (emodin and baicalin) and key pathway modulation. Preclinical evidence confirms efficacy through diagnostic hub genes and compound interactions, yet clinical application demands pharmacodynamic refinement.
Authors
- Weifeng Yu (ORCID: https://orcid.org/0000-0003-1979-6304)
- Quan Li (ORCID: https://orcid.org/0000-0003-0058-2672)
- Xuejiao Zhu
- Zhixia Chen (ORCID: https://orcid.org/0000-0002-5830-1485)
- Haichao Liu (ORCID: https://orcid.org/0009-0006-2311-7094)
- Jinquan Zhang (ORCID: https://orcid.org/0000-0001-5193-0687)
- Xiaona Chen (ORCID: https://orcid.org/0000-0002-5954-0701)
- Zhengzheng Yan
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/jir.s527378
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81