Dual RNA-seq analysis reveals the interaction between multidrug-resistant Klebsiella pneumoniae and host in a mouse model of pneumonia
In this mouse model of bacterial pneumonia, excessive siderophore expression may trigger the activation of hypoxia signaling pathways and the release of pro-inflammatory cytokines, ultimately reducing survival rates.
Authors
- Xiaolin Song
- Chengyu Sui
- Chenxi Dai (ORCID: https://orcid.org/0000-0003-1067-6402)
- Dongsheng Zhou (ORCID: https://orcid.org/0000-0003-3827-5969)
- Lingfei Hu (ORCID: https://orcid.org/0000-0001-7287-6800)
- Yongqiang Jiang (ORCID: https://orcid.org/0000-0001-7587-830X)
- Wenhui Yang (ORCID: https://orcid.org/0000-0001-8836-0278)
- Meng Lv (ORCID: https://orcid.org/0000-0002-7322-6743)
- C. H. Jiang
Institutions
- Army Medical University (CN)
- Academy of Military Medical Sciences (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s12866-025-04044-x
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Pathogen and Biosecurity