FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation
FAK inhibitors and increased FBP1 expression inhibit aerobic glycolysis in HSCs, thereby improving LF. Thus, FAK and FBP1 may be potential targets for LF treatment.
Authors
- Lu Han (ORCID: https://orcid.org/0000-0002-7062-6274)
- Houkang Pu (ORCID: https://orcid.org/0009-0002-0694-0872)
- Xueke Zhao (ORCID: https://orcid.org/0000-0002-3032-4933)
- Tao Huang (ORCID: https://orcid.org/0000-0001-5897-4017)
- Chen Pan (ORCID: https://orcid.org/0000-0002-1296-9770)
- Qingxiu Zhang (ORCID: https://orcid.org/0009-0001-0788-7228)
- Ya Zhang (ORCID: https://orcid.org/0000-0002-6013-0785)
- Lu Fan (ORCID: https://orcid.org/0000-0001-7227-2126)
- Ran Tao (ORCID: https://orcid.org/0000-0002-2576-6147)
- Yonghua Sun (ORCID: https://orcid.org/0000-0001-9368-6969)
- Shaojie Chen (ORCID: https://orcid.org/0000-0003-1377-0808)
- Huayue Wu (ORCID: https://orcid.org/0000-0003-3431-561X)
- Jinglin Wang (ORCID: https://orcid.org/0000-0002-7389-1022)
- Guo-Yuan Lin
- Yu-Mei Zhou
- Gao-Liang Zou (ORCID: https://orcid.org/0000-0002-9460-0802)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3748/wjg.v31.i28.107361
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32