Evidence that Mast Cells Regulate the Cough Hypersensitivity Associated with Eosinophilic Bronchitis
These results suggest that mast cells and not eosinophils may be essential to the emergence of cough hypersensitivity in EB. We speculate that therapeutic strategies targeting mast cells, cysLT<sub>1</sub> receptors, and TP receptors may represent endotype-specific treatments for chronic cough.
Authors
- Wai Haung Yu (ORCID: https://orcid.org/0000-0001-7186-6731)
- Brendan J. Canning (ORCID: https://orcid.org/0000-0003-4197-5560)
- Qi Liu (ORCID: https://orcid.org/0000-0002-3285-7864)
Institutions
- Tongji University (CN)
- Johns Hopkins University (US)
- Tongren Hospital (CN)
Publication Details
- Journal
- Lung
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1007/s00408-025-00835-1
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health