Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte
Our results indicate that PS-NPs cause mouse testicular damage through ferroptosis. Mechanistically, we confirmed that PS-NPs trigger NCOA4-mediated ferritinophagy and CISD1 downregulation in spermatocyte, which aggravates the flow of ferrous iron from the cytoplasm to the mitochondria.
Authors
- Guangyu Liu (ORCID: https://orcid.org/0000-0002-5865-431X)
- Yifan Wang (ORCID: https://orcid.org/0009-0001-9819-7379)
- Ning Liu (ORCID: https://orcid.org/0000-0003-2948-8161)
- Ziqi Wang (ORCID: https://orcid.org/0000-0003-1827-0458)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-9523-5296)
- Jing Lv (ORCID: https://orcid.org/0000-0003-2801-743X)
- Zhongliang Jiang (ORCID: https://orcid.org/0000-0001-7822-4520)
- Yuanyou Li (ORCID: https://orcid.org/0000-0002-3675-6024)
- Shayakhmetova Altyn
Institutions
- Sichuan University (CN)
- North West Agriculture and Forestry University (CN)
- Manash Kozybayev North Kazakhstan University (KZ)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s12951-025-03620-7
- Citations
- 9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Key Research and Development Projects of Shaanxi Province