uPAR and cFn as candidate protein biomarkers for identifying low response to rtPA in acute ischemic stroke
Our study suggests that uPAR and cFn may serve as the candidate markers for identifying low response to rtPA in AIS. Patients with a low plasma level of cFn or uPAR may present low response to rtPA and still suffer from a poor outcome with rtPA.
Authors
- Ziping Han
- Junfen Fan (ORCID: https://orcid.org/0000-0003-1892-5768)
- Yuyou Huang (ORCID: https://orcid.org/0000-0002-5830-1207)
- Yangmin Zheng
- Cesar V. Borlongan (ORCID: https://orcid.org/0000-0002-2966-9782)
- Liyuan Zhong (ORCID: https://orcid.org/0009-0006-5511-6432)
- Fangfang Li (ORCID: https://orcid.org/0000-0001-7695-7958)
- Yilin Wang (ORCID: https://orcid.org/0000-0002-8455-390X)
- Yumin Luo
- Lingzhi Li (ORCID: https://orcid.org/0000-0002-4308-0659)
- Zhenhong Yang
- Haiping Zhao (ORCID: https://orcid.org/0000-0003-1600-8982)
Institutions
- Capital Medical University (CN)
- Zhengzhou University (CN)
- Beijing Anzhen Hospital (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s40001-025-02772-4
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China