Inherited Mutations Shape Somatic Evolution and Cancer Risk

Major Finding: Germline variants increase clonal hematopoiesis by influencing somatic mutation patterns, thereby elevating blood cancer risk.Concept: Cancer risk reflects the interplay between inherited genetics and somatic mutation–driven clonal evolution in normal tissues.Impact: Germline–somatic interactions shape cancer risk trajectories, uncovering targets for personalized prevention and screening.

Publication Details

Journal: Cancer Discovery
Published: 2025-01-01
DOI: https://doi.org/10.1158/2159-8290.cd-rw2025-071
Primary Topic: Nutrition, Genetics, and Disease
Type: article
Field-Weighted Citation Impact: 0.00

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article

Inherited Mutations Shape Somatic Evolution and Cancer Risk

Jan 1, 2025

Cancer Discovery

Nutrition, Genetics, and Disease

article

Inherited Mutations Shape Somatic Evolution and Cancer Risk

January 1, 2025article en

Abstract

Cancer Discovery

Good health and well-being

Openalex Percentile: Top 79%

Nutrition, Genetics, and Disease

DOI Source OpenAlex

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Inherited Mutations Shape Somatic Evolution and Cancer Risk · Cancer Discovery (2025) | TGRS Research Map | TGRS