Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement
Our data indicate that microglial replacement-induced changes in the molecular heterogeneity and state transition of myeloid cells may be neuroprotective against acute brain injury.
Authors
- Xinru Pan
- Jian Gong (ORCID: https://orcid.org/0000-0002-4934-8599)
- Xiaoming Zheng (ORCID: https://orcid.org/0000-0001-7847-9793)
- Xiaoshuang Feng (ORCID: https://orcid.org/0000-0002-7933-3996)
- Jiaxin Xie (ORCID: https://orcid.org/0009-0005-4102-7060)
- Yi He (ORCID: https://orcid.org/0000-0001-5726-3686)
- Yufei Wang (ORCID: https://orcid.org/0000-0002-1960-3413)
- Pengfei Wang (ORCID: https://orcid.org/0000-0002-0285-2069)
- Haicheng Yuan
- Fang Xie (ORCID: https://orcid.org/0000-0002-6573-035X)
- Ming Ying (ORCID: https://orcid.org/0000-0003-2653-4273)
- Xiao-Yi Xiong
Institutions
- Qingdao University (CN)
- Linyi People's Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Weihai Municipal Hospital (CN)
- Science and Technology Department of Sichuan Province (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1625673
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68