Genome-wide association studies of Alzheimer’s disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans
Age, sex, and APOE-stratified analyses of dementia in AA participants from two cohorts revealed potential new associations. Stratified analyses may yield critical information about the genetic heterogeneity underlying dementia risk and lead to advances in precision medicine.
Authors
- Victoria C. Merritt (ORCID: https://orcid.org/0000-0001-5683-4168)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- J. Michael Gaziano
- Li‐San Wang (ORCID: https://orcid.org/0000-0002-3684-0031)
- Richard L. Hauger (ORCID: https://orcid.org/0000-0003-1509-1868)
- Margaret A. Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Richard Sherva (ORCID: https://orcid.org/0000-0003-2133-1493)
- Congcong Zhu (ORCID: https://orcid.org/0000-0002-1657-8726)
- Gerard D. Schellenberg (ORCID: https://orcid.org/0000-0003-1115-2475)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Rui Zhang (ORCID: https://orcid.org/0009-0003-6743-0021)
- Richard Mayeux
- Matthew S. Panizzon
- Vidriana Catanzaro
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- VA Boston Healthcare System (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- National Center for PTSD (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1186/s13195-025-01782-y
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Aging