Cancer-specific senescence signature promotes malignant phenotypes and immunotherapy resistance in colorectal cancer
Collectively, CSS drives tumor aggressiveness and independently predicts unfavorable survival outcomes and immunotherapy resistance in CRC. Notably, afatinib targeting of CSS selectively eliminated senescent cells via apoptosis while inhibiting tumor growth, highlighting its therapeutic potential for CSS-high malignancies.
Authors
- Bixia Duan
- Wei Wang (ORCID: https://orcid.org/0000-0001-9284-9586)
- Fengyu Ling
- Dong Huang (ORCID: https://orcid.org/0009-0005-1467-035X)
- Guomin Luo
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1603787
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University