Association between keratin 8 expression and immune-related pneumonitis: a case-control study in lung adenocarcinoma patients
Elevated KRT8 expression in tumor tissues is significantly associated with increased IRP risk in lung adenocarcinoma patients receiving immunotherapy. These exploratory, hypothesis-generating findings suggest that KRT8 expression may serve as a potential biomarker for predicting IRP development, though validation in larger cohorts is needed.
Authors
- Qi Mei (ORCID: https://orcid.org/0000-0002-9826-5044)
- Yang Yang (ORCID: https://orcid.org/0000-0001-6788-2843)
- Li Xu (ORCID: https://orcid.org/0000-0002-1359-0164)
- Hongxia Guo
- Yue Sun (ORCID: https://orcid.org/0000-0003-4713-5415)
- Xuena Wang (ORCID: https://orcid.org/0000-0002-7838-3692)
- Yuhui Ma
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1573943
- Citations
- 1
- Primary Topic
- Skin and Cellular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China
- Natural Science Foundation for Young Scientists of Shanxi Province