Insulin resistance as a mediator of the association between obesity, high-intensity binge drinking, and liver enzyme abnormalities in young and middle-aged adults: a cross-sectional study
The TyG index serves as a critical mediator in the synergistic effects of HIBD and obesity on liver enzyme abnormalities. Targeting IR and reducing the intensity of alcohol consumption may help mitigate liver injury in young and middle-aged adults with obesity.
Authors
- Andy S. K. Cheng (ORCID: https://orcid.org/0000-0001-7503-5273)
- Zitong Lu
- Nandan Chen
- Yinghong Li (ORCID: https://orcid.org/0000-0003-3629-519X)
- Yinglong Duan (ORCID: https://orcid.org/0000-0001-7126-2479)
- Yi Zhou (ORCID: https://orcid.org/0000-0003-4809-0749)
- Xiaoqian Dong
- Juan Luo
- Yuan Liu (ORCID: https://orcid.org/0000-0002-6326-1270)
- Jiayi Zhu
- Xingxing Wang (ORCID: https://orcid.org/0000-0002-9281-2043)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Third Xiangya Hospital (CN)
- Western Sydney University (AU)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fnut.2025.1554392
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Central South University
- Xiangya Hospital, Central South University