Integrated cytomembrane proteomics identifies EpCAM/MGST1 as therapeutic targets in metastatic laryngeal carcinoma
Integrated cytomembrane proteomics in metastatic LSCC unveils EpCAM/MGST1 as actionable immunotherapeutic targets, with silencing attenuating oncogenic proliferation, invasion, and Wnt/β-catenin-PI3K crosstalk, offering novel therapeutic avenues.
Authors
- Xiaohuang Lin (ORCID: https://orcid.org/0000-0002-0546-1637)
- Miao Gao
- Suling Zhuang
- Zhihan Li (ORCID: https://orcid.org/0000-0002-7218-2830)
- Xiaobo Wu (ORCID: https://orcid.org/0000-0002-4786-4637)
- Gongbiao Lin (ORCID: https://orcid.org/0000-0002-9333-9868)
- Shixin Wang
- Di Gan
- Xue Lin
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fgene.2025.1615570
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province