Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment
These findings highlight the importance of TG2 in the TME for ovarian cancer metastasis, potentially by activation of humoral immunity and specifically highlight a crucial role for TG2 in modulating B cells to prolong survival in mouse models of ovarian cancer.
Authors
- Jeffrey W. Keillor (ORCID: https://orcid.org/0000-0002-8133-6862)
- Mélanie Grondin (ORCID: https://orcid.org/0009-0004-1655-7740)
- Barbara C. Vanderhyden (ORCID: https://orcid.org/0000-0002-7644-7189)
- Emily A. Thompson (ORCID: https://orcid.org/0000-0002-4383-5249)
- Sarah Nersesian (ORCID: https://orcid.org/0000-0003-1283-2077)
- John Abou‐Hamad (ORCID: https://orcid.org/0009-0004-9407-9043)
- Kristianne J.C. Galpin (ORCID: https://orcid.org/0000-0002-4199-6874)
- Galaxia M. Rodriguez (ORCID: https://orcid.org/0000-0002-5366-6047)
- Pauline Navals (ORCID: https://orcid.org/0000-0002-2703-429X)
- Sara Asif
- David P. Cook (ORCID: https://orcid.org/0000-0001-7639-6724)
- Maryam Echaibi
- Elizabeth A. Macdonald (ORCID: https://orcid.org/0000-0002-3154-9632)
- Dalia Ibrahim (ORCID: https://orcid.org/0000-0003-0335-9548)
- B. P. K. Ryan
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Ottawa University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1639853
- Citations
- 1
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Canadian Institutes of Health Research