Pharmacognostic and Anti-Acne Evaluation of Calendula Officinalis L. And Carica Papaya L. Extracts

Background: Calendula officinalis and Carica papaya are two indigenous plants bearing important bioactive phytoconstituents which can serve as natural antibiotic. Antibiotic resistance has become a menace of today’s medical world which could only be managed by newer and safer antibiotics. Objective: This research project was designed to find out the antimicrobial effects of Calendula officinalis and Carica papaya against acne producing organisms which can lead to anti acne organic drug Methodology: The plants were collected and identified for research study as per standard practice. The selected parts of plants i.e. Carica papaya fruit and Calendula officinalis flowers were observed through powdered microscopy for major diagnostic elements in organ cells. Then the extracts were prepared through conventional methods. These extracts were tested for phytoconstituents and antimicrobial activity against ATCC strains of Staphylococcus aureus. Staphylococcus epidermidis and Propionibacterium acnes. Results: Microscopic study revealed presence of scleroids, fibres, trichomes in both herbs Oil globules found in calendula while oxalates in papaya extract. Phytochemical analysis confirmed the presence of important metabolites like alkaloids, glycosides, flavonoids, terpenoids, saponins, tannins and phenolic compounds. Highly significant antimicrobial activity was found in both extracts against S. aureus and P. acnes while mild significant against S. epidermidis. Conclusion: The results clearly indicates that both herbs possess highly significant anti-acne activity which may be further be proceeded for formulation of suitable anti-acne cream.