Risk of clinical events in virologically suppressed people with HIV switching to a two-drug regimen vs. remaining on a three-drug regimen: a target trial emulation
The Icona Foundation Study is supported by unrestricted grants from Gilead Sciences, ViiV Healthcare, Merck Sharpe & Dohme.
Authors
- Ilaria Coledan
- F von Schloesser
- Silvia Lamonica
- Antonio Di Biagio (ORCID: https://orcid.org/0000-0003-1436-5089)
- S De Benedittis
- Miriam Lichtner (ORCID: https://orcid.org/0000-0002-7730-3953)
- Giovanni Guaraldi (ORCID: https://orcid.org/0000-0002-5724-3914)
- Ylenia Russotto (ORCID: https://orcid.org/0000-0001-9514-133X)
- Cristina Marelli
- Eugenio Milano (ORCID: https://orcid.org/0000-0002-6113-223X)
- Spinello Antinori (ORCID: https://orcid.org/0000-0003-0569-9407)
- Gabriella d’Ettorre (ORCID: https://orcid.org/0000-0002-3571-5677)
- Massimo Puoti (ORCID: https://orcid.org/0000-0003-3278-7138)
- Roberto Rossotti (ORCID: https://orcid.org/0000-0003-4965-8789)
- Katia Falasca (ORCID: https://orcid.org/0000-0002-8795-5410)
- Lucia Taramasso (ORCID: https://orcid.org/0000-0002-6622-6358)
- Carmen Rita Santoro (ORCID: https://orcid.org/0000-0001-7806-8548)
- Carmela Pinnetti
- Riccardo Lolatto
- Nicoletta Policek (ORCID: https://orcid.org/0000-0002-5788-4869)
- Andrea De Vito (ORCID: https://orcid.org/0000-0002-8265-5400)
- Viviana Rizzo (ORCID: https://orcid.org/0009-0004-4289-0563)
- Stefania Carrara (ORCID: https://orcid.org/0000-0002-4562-797X)
- Loredana Sarmati (ORCID: https://orcid.org/0000-0003-1452-0333)
- Alessandro Tavelli (ORCID: https://orcid.org/0000-0001-5899-451X)
- Laura Comi (ORCID: https://orcid.org/0000-0002-0848-2847)
- Francesco Maria Fusco (ORCID: https://orcid.org/0000-0002-1293-5976)
- Adriano Lazzarin (ORCID: https://orcid.org/0000-0003-2551-7754)
- Marcello Trizzino (ORCID: https://orcid.org/0000-0002-8105-5139)
- Roberto Cauda
- Massimo Giotta (ORCID: https://orcid.org/0000-0002-7041-7851)
- Luchino Chessa (ORCID: https://orcid.org/0000-0002-9474-0995)
- Paolo Maggi (ORCID: https://orcid.org/0000-0002-8772-0136)
- Maria Maddalena Plazzi (ORCID: https://orcid.org/0000-0002-1574-1552)
- Massimiliano Fabbiani (ORCID: https://orcid.org/0000-0002-1343-812X)
- Claudio Maria Mastroianni (ORCID: https://orcid.org/0000-0002-1286-467X)
- Roberta Rovito (ORCID: https://orcid.org/0000-0002-8640-844X)
- Andrea Antinori (ORCID: https://orcid.org/0000-0003-2121-4684)
- Anna Maria Cattelan (ORCID: https://orcid.org/0000-0003-2869-2945)
- Andrea Costantini (ORCID: https://orcid.org/0000-0003-1588-7030)
- N Sangiovanni
- Alessandra Latini (ORCID: https://orcid.org/0000-0002-9421-6560)
- Camilla Tincati (ORCID: https://orcid.org/0000-0002-3083-2962)
- Loredana Alessio (ORCID: https://orcid.org/0000-0001-9748-4328)
- Giancarlo Iaiani
- Andrea Calcagno (ORCID: https://orcid.org/0000-0003-2534-8815)
- Adriana Cervo (ORCID: https://orcid.org/0000-0002-1384-7847)
- Matteo Bassetti (ORCID: https://orcid.org/0000-0002-0145-9740)
- Giulio Starnini
- Emanuele Focà (ORCID: https://orcid.org/0000-0003-4395-5379)
- Serena Dell’Isola
- Benedetto Maurizio Celesia (ORCID: https://orcid.org/0000-0002-6919-1955)
- Antonella Cingolani (ORCID: https://orcid.org/0000-0002-3793-2755)
- Chiara Molteni (ORCID: https://orcid.org/0000-0003-4746-3750)
- Nicoletta Bobbio
- Federica Sozio
- Romina Corsini
- Lorenzo Badia (ORCID: https://orcid.org/0000-0001-5694-1158)
- Sarah Dal Zoppo
- Daniela Francisci (ORCID: https://orcid.org/0000-0001-8752-8278)
- Alessandro Cozzi‐Lepri (ORCID: https://orcid.org/0000-0002-6339-919X)
- Valeria Calvino (ORCID: https://orcid.org/0009-0003-3789-3092)
- Antonella Castagna (ORCID: https://orcid.org/0000-0002-8338-9714)
- G Pellicanò
- V Barocci
- Elisabetta Schiaroli (ORCID: https://orcid.org/0000-0002-3216-4144)
- Gianluca Prota
- Giovanni Lapadula (ORCID: https://orcid.org/0000-0002-8427-6092)
- Alessia Lai (ORCID: https://orcid.org/0000-0002-3174-5721)
- Stefano Rusconi (ORCID: https://orcid.org/0000-0002-0375-9990)
- Daniela Messeri
- Nicola Squillace (ORCID: https://orcid.org/0000-0002-7608-6045)
- Claudia Suardi
- Francesco Pes (ORCID: https://orcid.org/0000-0001-7645-1594)
- Vincenzo Sangiovanni
- Barbara Suligoi (ORCID: https://orcid.org/0000-0001-9623-7659)
- Angela Londero
- Filippo Bartalesi (ORCID: https://orcid.org/0000-0002-1166-3323)
- Ivano Mezzaroma (ORCID: https://orcid.org/0000-0003-2855-6425)
- Emanuele Pontali (ORCID: https://orcid.org/0000-0002-1085-0442)
- Vincenzo Spagnuolo (ORCID: https://orcid.org/0000-0002-9656-7217)
- Marco Rivano Capparuccia (ORCID: https://orcid.org/0000-0002-0367-6941)
- Antonio Cascio (ORCID: https://orcid.org/0000-0002-1992-1796)
- Alessandra Vergori (ORCID: https://orcid.org/0000-0001-6944-0686)
- C Abeli
- A Perziano (ORCID: https://orcid.org/0000-0002-3452-8124)
- C Stingone
- Johanna Chester (ORCID: https://orcid.org/0000-0003-2866-0783)
- Donatella Vincenti (ORCID: https://orcid.org/0000-0002-1821-4248)
- Silvia Truffa
- R Iardino (ORCID: https://orcid.org/0009-0003-8474-644X)
- Valentina Mazzotta (ORCID: https://orcid.org/0000-0002-0240-7504)
- Silvia Graziano (ORCID: https://orcid.org/0000-0002-5609-0872)
- Nicola Coppola (ORCID: https://orcid.org/0009-0000-3202-5489)
- Beatrice Borchi (ORCID: https://orcid.org/0000-0002-4063-5225)
- Maria Luisa Cosmaro
- Silvia Nozza (ORCID: https://orcid.org/0000-0002-2673-2731)
- Giovanni Di Filippo
- V L Del Negro
- Massimo Cernuschi (ORCID: https://orcid.org/0000-0001-9229-7435)
- Ilaria Mastrorosa (ORCID: https://orcid.org/0000-0003-1944-662X)
- Barbara Menzaghi (ORCID: https://orcid.org/0000-0002-5073-6521)
- Marisa Fusto
- Francesca Ceccherini‐Silberstein (ORCID: https://orcid.org/0000-0002-6024-5101)
- Ivan Gentile (ORCID: https://orcid.org/0000-0002-5199-8451)
- Alessandra Bandera (ORCID: https://orcid.org/0000-0001-9440-4601)
- Carlo Tascini (ORCID: https://orcid.org/0000-0001-9625-6024)
- Matteo Augello (ORCID: https://orcid.org/0000-0002-1031-9504)
- Iuri Fanti
- Laura Pezzati (ORCID: https://orcid.org/0000-0002-7306-342X)
- C Lazzaretti
- Giustino Parruti (ORCID: https://orcid.org/0000-0003-3483-8170)
- Marta Camici (ORCID: https://orcid.org/0000-0002-6624-7917)
- Giulia Marchetti (ORCID: https://orcid.org/0000-0002-4498-4828)
- Salvatore Martini
- A Rodano’
- Valeria Bono (ORCID: https://orcid.org/0000-0003-2182-5434)
- M Capozzi
- Guido Calleri (ORCID: https://orcid.org/0000-0002-8440-1922)
- Giordano Madeddu (ORCID: https://orcid.org/0000-0001-6099-2273)
- Antonella d’Arminio Monforte (ORCID: https://orcid.org/0000-0003-0073-1789)
- Maria Vittoria Cossu (ORCID: https://orcid.org/0000-0002-6984-3028)
- Massimo Farinella
- Roberta Gagliardini
- Valentina Svicher (ORCID: https://orcid.org/0000-0002-2377-504X)
- Stefania Piconi
- Paolo Bonfanti (ORCID: https://orcid.org/0000-0001-7289-8823)
- Annalisa Saracino (ORCID: https://orcid.org/0000-0001-9558-208X)
- Sara Irene Bonelli
- Cristina Mussini
- Sergio Lo Caputo (ORCID: https://orcid.org/0000-0002-4729-7548)
- Paola Cinque (ORCID: https://orcid.org/0000-0003-2448-5957)
- Elke Erne (ORCID: https://orcid.org/0000-0002-9295-7998)
- Nicola Gianotti (ORCID: https://orcid.org/0000-0002-7182-5080)
- Giulia Mancarella (ORCID: https://orcid.org/0009-0007-4143-5894)
- Giuliana Battagin
- Silvia Cretella (ORCID: https://orcid.org/0009-0000-1249-1618)
- Jacopo Vecchiet (ORCID: https://orcid.org/0000-0001-9250-4844)
- Carlo Federico Perno (ORCID: https://orcid.org/0000-0002-0825-5388)
- Sara Diotallevi (ORCID: https://orcid.org/0009-0003-2559-7042)
- G Canavesi
- Vincenzo Esposito (ORCID: https://orcid.org/0000-0003-4696-2363)
- Angelo Pan (ORCID: https://orcid.org/0000-0003-2340-4916)
- Cecilia Costa (ORCID: https://orcid.org/0000-0002-2255-1271)
- Giuseppe Nunnari (ORCID: https://orcid.org/0000-0002-7269-1539)
- Alessandro Bartoloni (ORCID: https://orcid.org/0000-0001-9758-1523)
- Vincenzo Malagnino (ORCID: https://orcid.org/0000-0002-6561-5298)
- Annalisa Mondi (ORCID: https://orcid.org/0000-0003-4096-2610)
- Daniela Segala (ORCID: https://orcid.org/0000-0001-6133-0386)
- Diana Canetti
- Pierluigi Viale
- Cosmo Del Borgo (ORCID: https://orcid.org/0000-0002-7715-1232)
- Francesca Montagnani
- Maria Mercedes Santoro
- Stefano Bonora
- Carlo Torti
- Eugenia Quiros-Roldan
- Enrico Girardi
- Rosa Fontana Del Vecchio
- Andrea Gori
- Franco Maggiolo
- Sergio Ferrara (ORCID: https://orcid.org/0000-0003-0377-9630)
- Laura Gianserra
- Simone Lanini
- Antonina Franco
- Daria Russo
- A. Pieri (ORCID: https://orcid.org/0009-0008-7760-3260)
- Sabrina Blanchi
- Stefano Nicolè
- Davide Leoni
- Maria Cristina Moioli
- Giovanni Di Perri
- Giancarlo Orofino
- Raffaella Marocco
- M Menozzi
- Guido Accardo
Institutions
- University of Rome Tor Vergata (IT)
- University of Modena and Reggio Emilia (IT)
- Marche Polytechnic University (IT)
- Vita-Salute San Raffaele University (IT)
- University of Sassari (IT)
- University of Pavia (IT)
- Policlinico Umberto I (IT)
- National Institute for Health and Care Research (GB)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- IRCCS Ospedale San Raffaele (IT)
- Policlinico Tor Vergata (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASST Fatebenefratelli Sacco (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University College London (GB)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- EClinicalMedicine
- Published
- 2025-07-24
- DOI
- https://doi.org/10.1016/j.eclinm.2025.103368
- Citations
- 2
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Pfizer
- AstraZeneca
- Gilead Sciences
- ViiV Healthcare
- Moderna
- European Commission
- Bavarian Nordic
- Cilag