Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis

These findings suggest that 77-39 may serve as a novel therapeutic agent for GCTs by targeting SIRT3 and modulating the p53 and NF-κB pathways.

Authors

Xueqing Wu (ORCID: https://orcid.org/0000-0001-8013-5770)
Wenhao Wu (ORCID: https://orcid.org/0000-0003-3449-6246)
Lijun Fan (ORCID: https://orcid.org/0000-0001-5863-0169)
Shunichi Takeda (ORCID: https://orcid.org/0000-0002-7924-7991)
Jingxin Ma
Xiushen Li (ORCID: https://orcid.org/0000-0002-7135-7299)
Guli Zhu
Qi Zhang (ORCID: https://orcid.org/0000-0002-5055-3637)
Xiaoyu Li
Zhou Yu (ORCID: https://orcid.org/0000-0002-2358-0090)
Chuimian Zeng
Qiongfang Fang
Sailing Lin

Institutions

Sun Yat-sen University (CN)
China Pharmaceutical University (CN)
Shenzhen University (CN)
Jiangxi Maternal and Child Health Hospital (CN)
State Key Laboratory of Synthetic Chemistry (CN)
University of Hong Kong (HK)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2025-07-24
DOI: https://doi.org/10.3389/fphar.2025.1608156
Primary Topic: Sirtuins and Resveratrol in Medicine
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Shenzhen Municipal Science and Technology Innovation Council

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article

Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis

Xueqing Wu, Wenhao Wu, Lijun Fan, Shunichi Takeda et al.

Jul 24, 2025

Frontiers in Pharmacology

Sirtuins and Resveratrol in Medicine

article

Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis

Xueqing Wu, Wenhao Wu, Lijun Fan, Shunichi Takeda, Jingxin Ma, Xiushen Li, Guli Zhu, Qi Zhang, Xiaoyu Li, Zhou Yu, Chuimian Zeng, Qiongfang Fang, Sailing Lin

July 24, 2025article en

Abstract

These findings suggest that 77-39 may serve as a novel therapeutic agent for GCTs by targeting SIRT3 and modulating the p53 and NF-κB pathways.

Frontiers in PharmacologyVol. 16

Sun Yat-sen University (CN), China Pharmaceutical University (CN), Shenzhen University (CN), Jiangxi Maternal and Child Health Hospital (CN), State Key Laboratory of Synthetic Chemistry (CN), University of Hong Kong (HK)

Shenzhen Municipal Science and Technology Innovation Council

Good health and well-being

Openalex Percentile: Top 79%

Sirtuins and Resveratrol in Medicine

DOI Open Access PDF OpenAlex

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Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis — Xueqing Wu, Wenhao Wu, et al. · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS