The active metabolites of Eucommia ulmoides leaves alleviate atherosclerosis induced by a high-fat diet and VD3 in rats
EUL 50, an active metabolite from <i>E. ulmoides</i> leaves, demonstrates potential in preventing and treating AS through autophagy-mediated regulation of NLRP3 inflammasomes. These findings support the potential development of health products derived from <i>E. ulmoides</i> leaves.
Authors
- Zhimin Wang (ORCID: https://orcid.org/0000-0003-0771-9125)
- Liping Dai (ORCID: https://orcid.org/0000-0002-1910-7591)
- Bingdi Cui
- Xiaoqian Liu (ORCID: https://orcid.org/0009-0006-1919-6519)
- Li Zhu (ORCID: https://orcid.org/0000-0001-5249-6536)
- Cong Ling (ORCID: https://orcid.org/0000-0003-3953-0108)
- Man Gong
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fphar.2025.1625200
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Henan University of Chinese Medicine
- National Natural Science Foundation of China
- Henan University
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China