Metabolome-wide associations with short-term exposure to PM2.5-bound polycyclic aromatic hydrocarbons: a study in older adults
The plasma metabolome presents a promising resource for biomarkers and pathways, elucidating the biological mechanisms of PM<sub>2.5</sub>-bound PAHs. Our findings suggest that the cholesterol and citric acid metabolites, as well as the cholesterol biosynthesis and citric acid cycle pathways they affect, may play important roles in the health damage caused by PAHs, providing potential insights into the pathogenic processes underlying the impact of PM<sub>2.5</sub>-bound PAHs.
Authors
- Dandan Zhu (ORCID: https://orcid.org/0000-0003-0279-082X)
- Shuling Kang
- Jing Hui Wu (ORCID: https://orcid.org/0000-0002-6012-2785)
- Chuancheng Wu (ORCID: https://orcid.org/0000-0003-2101-4738)
- Huaying Lin
- Jin Li (ORCID: https://orcid.org/0000-0001-9201-2321)
- Jiang Yu (ORCID: https://orcid.org/0000-0002-4436-707X)
- Zhiwei Chen (ORCID: https://orcid.org/0009-0002-0246-5453)
- Kang Cao (ORCID: https://orcid.org/0009-0009-2915-1455)
- Jianjun Xiang (ORCID: https://orcid.org/0000-0001-8107-2580)
- Quan Zhou
- H. M. Hu
Institutions
- Fujian Medical University (CN)
- Quanzhou Normal University (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fpubh.2025.1609724
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00