Efficacy and safety of peripherally-restricted κ-opioid receptor agonist-HSK21542 for postoperative analgesia in patients undergoing laparoscopic abdominal surgery: a randomized, placebo-controlled phase 2 trial
Authors
- Min Yan (ORCID: https://orcid.org/0000-0002-1355-1261)
- Xiaoling Hu (ORCID: https://orcid.org/0000-0003-3188-3005)
- Qulian Guo (ORCID: https://orcid.org/0000-0002-5636-8491)
- Dong‐Xin Wang (ORCID: https://orcid.org/0000-0002-3205-1836)
- Hongmeng Xu (ORCID: https://orcid.org/0000-0002-7493-854X)
- Mengchang Yang
- Nan Ling
- Haiying Wang (ORCID: https://orcid.org/0000-0001-5028-7837)
- Zhiping Wang (ORCID: https://orcid.org/0000-0001-5217-0982)
- Jiaqiang Zhang (ORCID: https://orcid.org/0000-0002-1367-9644)
- Jinglei Wu (ORCID: https://orcid.org/0000-0001-9549-3992)
- Qiang Xu (ORCID: https://orcid.org/0000-0003-1797-6256)
- Jianjun Yang (ORCID: https://orcid.org/0000-0002-8332-5526)
- Yinbo Zhong
Institutions
- Hebei Medical University (CN)
- Union Hospital (HK)
- Central South University (CN)
- University of Electronic Science and Technology of China (CN)
- Xuzhou Medical College (CN)
- Peking University (CN)
- Liuzhou General Hospital (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Peking University First Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
- First Affiliated Hospital of University of South China (CN)
- First Bethune Hospital of Jilin University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Xiangya Hospital Central South University (CN)
- Huazhong University of Science and Technology (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fmed.2025.1604790
- Citations
- 2
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 4.01