Primary vs. second primary cT1-T2 oral squamous cell carcinoma: comparing the outcomes
This study confirms second primary malignancies as a key prognostic factor for survival in OSCC. Male sex, advanced TNM stage, gross ENE, multiple lymph node involvement, and active smoking status were linked to poorer outcomes. Larger studies with multivariate analysis comparing primary and non-primary tumors are needed to validate these findings.
Authors
- Paul M. Clément (ORCID: https://orcid.org/0000-0001-7600-0806)
- Jeroen Meulemans (ORCID: https://orcid.org/0000-0003-1761-1222)
- Vincent Vander Poorten (ORCID: https://orcid.org/0000-0003-1341-829X)
- Annouschka Laenen (ORCID: https://orcid.org/0000-0002-1371-442X)
- Sandra Nuyts (ORCID: https://orcid.org/0000-0002-5540-4796)
- Davide Di Santo (ORCID: https://orcid.org/0000-0002-8239-3850)
- Noëmi Ramirez-Guanche
- Fien Jaeken
Institutions
- Statistics Belgium (BE)
- Catholic University of America (US)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fsurg.2025.1610776
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- KU Leuven