AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells
Increased DC signaling, including NOTCH, through AS04 in Cervarix supports cell survival and sustained RNA translation in memory B cells, 7 days post-vaccination. This may enhance adaptive immune cell maturation, providing a mechanism that can lead to improved cross-reactivity.
Authors
- Martin Müller (ORCID: https://orcid.org/0000-0001-7740-7798)
- Anthony Willems (ORCID: https://orcid.org/0009-0006-7257-4419)
- Isabel Leroux‐Roels (ORCID: https://orcid.org/0000-0002-5084-4696)
- Peter Sehr (ORCID: https://orcid.org/0000-0002-4348-5066)
- Ashish Sharma (ORCID: https://orcid.org/0000-0001-9444-7046)
- Rafick‐Pierre Sékaly (ORCID: https://orcid.org/0000-0002-7816-4828)
- Alfredo Santana (ORCID: https://orcid.org/0000-0002-1075-9948)
- Marthe Pauwels
- Gwenn Waerlop (ORCID: https://orcid.org/0000-0003-3712-2979)
- Fien De Boever
- Tim Waterboer (ORCID: https://orcid.org/0000-0002-0616-6963)
- Geert Leroux–Roels
- Valentino D’Onofrio (ORCID: https://orcid.org/0000-0003-3828-0442)
Institutions
- Emory University (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Ghent University Hospital (BE)
- European Molecular Biology Laboratory (DE)
- Atlanta VA Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1623405
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Emory University
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering