Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection
Our study uncovers a dual-stage regulatory role of Themis in TFH cell differentiation during chronic viral infection. While promoting TFH generation early, Themis unexpectedly restrains excessive differentiation at later stages, suggesting its function is context- and time-dependent. These findings highlight Themis as a key temporal regulator of CD4⁺ T cell fate decisions under chronic antigenic stress.
Authors
- Lichao Hou
- Cong Yu (ORCID: https://orcid.org/0000-0001-9398-3795)
- Yanping Du (ORCID: https://orcid.org/0000-0001-6730-3178)
- Bing Xu (ORCID: https://orcid.org/0000-0002-7271-4438)
- Qifeng Gan
- Nicholas R. J. Gascoigne (ORCID: https://orcid.org/0000-0001-9980-4225)
- Guo Fu (ORCID: https://orcid.org/0000-0001-5451-5219)
- Minxue Quan
- Qi‐Fan Zheng
- Chadakan Yan (ORCID: https://orcid.org/0000-0002-5347-5822)
- Xiaobin Zhang (ORCID: https://orcid.org/0000-0002-0577-5951)
- Yuzhen Zhu
- Ning Wang (ORCID: https://orcid.org/0009-0004-7037-9260)
- Siyi Liu (ORCID: https://orcid.org/0009-0009-4609-6072)
- Jian Tang
- Shuo Lin (ORCID: https://orcid.org/0000-0003-2317-0339)
- Bowen Hou (ORCID: https://orcid.org/0000-0002-1974-8938)
- Yuzhou Bao
Institutions
- National University of Singapore (SG)
- Xiamen University (CN)
- Augusta University (US)
- First Affiliated Hospital of Xiamen University (CN)
- Augusta University Health (US)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1638178
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Ministry of Education, India
- Xiamen University