Deep brain stimulation in globus pallidus internus travels to thalamus and subthalamic nuclei along physiological pathways
These results suggest that DBS engages existing motor pathways to reach distant targets, offering mechanistic insight into its network effects. This supports future approaches that could tailor treatment plans based on individual connectivity maps to improve clinical efficacy of DBS.
Authors
- Estefanía Hernández‐Martín (ORCID: https://orcid.org/0000-0002-9745-3254)
- Terence D. Sanger (ORCID: https://orcid.org/0000-0002-1837-6044)
- Maral Kasiri
- Jessica Vidmark (ORCID: https://orcid.org/0000-0001-8351-7467)
- S. Alireza Seyyed Mousavi
Institutions
- Children's Hospital of Orange County (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-07-24
- DOI
- https://doi.org/10.3389/fnins.2025.1592689
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Cerebral Palsy Alliance Research Foundation
- Cerebral Palsy Alliance